Intrahepatic Cholestatic Hepatitis after Ajmaline and Flecainide Application in a Patient with Ventricular Tachycardia and Cyp2d6 Polymorphism
نویسندگان
چکیده
Intrahepatic cholestatic hepatitis is a rare but therapy-limiting side effect of antiarrhythmic drugs, in literature only few reports are related to the subscription of ajmaline [1-3]. As potential causes for development of intrahepatic cholestatic hepatitis drug-triggered autoimmune reactions as well as direct toxic effects are recently discussed. However, the mechanism of this severe hepatic side effect remains unclear.
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